MTHFR DMS

Deep mutational scan of human MTHFR based on functional complementation in yeast, at three different concentrations of folate (12, 25 and 100 ug/ml ) and in two genetic backgrounds (WT / A222V)

urn:mavedb:00000049-a

Created Feb. 27, 2019
Last updated Nov. 20, 2020
Published Nov. 20, 2020
Member of urn:mavedb:00000049

Score sets

urn:mavedb:00000049-a-1

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urn:mavedb:00000049-a-2

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urn:mavedb:00000049-a-3

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urn:mavedb:00000049-a-4

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urn:mavedb:00000049-a-5

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urn:mavedb:00000049-a-6

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urn:mavedb:00000049-a-7

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urn:mavedb:00000049-a-8

Abstract

No abstract has been provided for this entry.

Method

No method has been provided for this entry.

References

No associated publications.

Contributors

Keywords

Targets

Name: MTHFR

Type: Protein coding

Organism: Homo sapiens

Reference genome: hg38

Reference assembly: Other/Synthetic

Reference sequence: ATGGTGAACGAAGCCAGAGGAAACAGCAGCCTCAACCCCTGCTTGGAGGGCAGTGCCAGCAGTGGCAGTGAGAGCTCCAAAGATAGTTCGAGATGTTCCACCCCGGGCCTGGACCCCGAGCGGCATGAGAGACTCCGGGAGAAGATGAGGCGGCGATTGGAATCTGGTGACAAGTGGTTCTCCCTGGAATTCTTCCCTCCTCGAACTGCTGAGGGAGCTGTCAATCTCATCTCAAGGTTTGACCGGATGGCAGCAGGTGGCCCCCTCTACATAGACGTGACCTGGCACCCAGCAGGTGACCCTGGCTCAGACAAGGAGACCTCCTCCATGATGATCGCCAGCACCGCCGTGAACTACTGTGGCCTGGAGACCATCCTGCACATGACCTGCTGCCGTCAGCGCCTGGAGGAGATCACGGGCCATCTGCACAAAGCTAAGCAGCTGGGCCTGAAGAACATCATGGCGCTGCGGGGAGACCCAATAGGTGACCAGTGGGAAGAGGAGGAGGGAGGCTTCAACTACGCAGTGGACCTGGTGAAGCACATCCGAAGTGAGTTTGGTGACTACTTTGACATCTGTGTGGCAGGTTACCCCAAAGGCCACCCCGAAGCAGGGAGCTTTGAGGCTGACCTGAAGCACTTGAAGGAGAAGGTGTCTGCGGGAGCCGATTTCATCATCACGCAGCTTTTCTTTGAGGCTGACACATTCTTCCGCTTTGTGAAGGCATGCACCGACATGGGCATCACTTGCCCCATCGTCCCCGGGATCTTTCCCATCCAGGGCTACCACTCCCTTCGGCAGCTTGTGAAGCTGTCCAAGCTGGAGGTGCCACAGGAGATCAAGGACGTGATTGAGCCAATCAAAGACAACGATGCTGCCATCCGCAACTATGGCATCGAGCTGGCCGTGAGCCTGTGCCAGGAGCTTCTGGCCAGTGGCTTGGTGCCAGGCCTCCACTTCTACACCCTCAACCGCGAGATGGCTACCACAGAGGTGCTGAAGCGCCTGGGGATGTGGACTGAGGACCCCAGGCGTCCCCTACCCTGGGCTCTCAGCGCCCACCCCAAGCGCCGAGAGGAAGATGTACGTCCCATCTTCTGGGCCTCCAGACCAAAGAGTTACATCTACCGTACCCAGGAGTGGGACGAGTTCCCTAACGGCCGCTGGGGCAATTCCTCTTCCCCTGCCTTTGGGGAGCTGAAGGACTACTACCTCTTCTACCTGAAGAGCAAGTCCCCCAAGGAGGAGCTGCTGAAGATGTGGGGGGAGGAGCTGACCAGTGAAGAAAGTGTCTTTGAAGTCTTCGTTCTTTACCTCTCGGGAGAACCAAACCGGAATGGTCACAAAGTGACTTGCCTGCCCTGGAACGATGAGCCCCTGGCGGCTGAGACCAGCCTGCTGAAGGAGGAGCTGCTGCGGGTGAACCGCCAGGGCATCCTCACCATCAACTCACAGCCCAACATCAACGGGAAGCCGTCCTCCGACCCCATCGTGGGCTGGGGCCCCAGCGGGGGCTATGTCTTCCAGAAGGCCTACTTAGAGTTTTTCACTTCCCGCGAGACAGCGGAAGCACTTCTGCAAGTGCTGAAGAAGTACGAGCTCCGGGTTAATTACCACCTTGTCAATGTGAAGGGTGAAAACATCACCAATGCCCCTGAACTGCAGCCGAATGCTGTCACTTGGGGCATCTTCCCTGGGCGAGAGATCATCCAGCCCACCGTAGTGGATCCCGTCAGCTTCATGTTCTGGAAGGACGAGGCCTTTGCCCTGTGGATTGAGCGGTGGGGAAAGCTGTATGAGGAGGAGTCCCCGTCCCGCACCATCATCCAGTACATCCACGACAACTACTTCCTGGTCAACCTGGTGGACAATGACTTCCCACTGGACAACTGCCTCTGGCAGGTGGTGGAAGACACATTGGAGCTTCTCAACAGGCCCACCCAGAATGCGAGAGAAACGGAGGCTCCATGA

External identifiers

DOI: No associated DOIs

Raw reads: No associated raw reads

Score sets

  • urn:mavedb:00000049-a-1

    MTHFR at 100ug/ml folate in WT background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 100ug/ml folate in WT background

  • urn:mavedb:00000049-a-2

    MTHFR at 25ug/ml folate in A222V background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 25ug/ml folate in A222V background

  • urn:mavedb:00000049-a-3

    MTHFR at 100ug/ml folate in A222V background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 100ug/ml folate in A222V background

  • urn:mavedb:00000049-a-4

    MTHFR at 12ug/ml folate in WT background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 12ug/ml folate in WT background

  • urn:mavedb:00000049-a-5

    MTHFR at 12ug/ml folate in A222V background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 12ug/ml folate in A222V background

  • urn:mavedb:00000049-a-6

    MTHFR at 25ug/ml folate in WT background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 25ug/ml folate in WT background

  • urn:mavedb:00000049-a-7

    MTHFR at 200ug/ml folate in WT background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 200ug/ml folate in WT background

  • urn:mavedb:00000049-a-8

    MTHFR at 200ug/ml folate in A222V background

    A deep mutational scan of human MTHFR via functional complementation in yeast at 200ug/ml folate in A222V background